Endothelium-specific Cre recombinase activity in flk-1-Cre transgenic mice
نویسندگان
چکیده
منابع مشابه
Podocyte-specific expression of cre recombinase in transgenic mice.
We report a transgenic mouse line that expresses Cre recombinase exclusively in podocytes. Twenty- four transgenic founders were generated in which Cre recombinase was placed under the regulation of a 2.5-kb fragment of the human NPHS2 promoter. Previously, this fragment was shown to drive beta-galactosidase (beta-gal) expression exclusively in podocytes of transgenic mice. For analysis, founde...
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PURPOSE Gene inactivation with homologous recombination in mice is a widely used tool to study gene function. However, many proteins play essential roles in a number of tissues and germline gene inactivation often results in embryonic lethality. To overcome this limitation and to dissect the functions of essential genes beyond embryonic development, we generated mouse rod opsin promoter-control...
متن کاملAn androgen-inducible proximal tubule-specific Cre recombinase transgenic model.
To facilitate the study of renal proximal tubules, we generated a transgenic mouse strain expressing an improved Cre recombinase (iCre) under the control of the kidney androgen-regulated protein (KAP) promoter. The transgene was expressed in the kidney of male mice but not in female mice. Treatment of female transgenic mice with androgen induced robust expression of the transgene in the kidney....
متن کاملPodocyte-specific expression of tamoxifen-inducible Cre recombinase in mice.
BACKGROUND Podocytes play an important role in maintaining normal glomerular function. A podocyte-specific conditional knockout technology has been established by the use of transgenic mice expressing a podocyte-specific Cre recombinase to clarify the role of genes expressed in the podocytes. However, it may be difficult to examine the role of genes in certain pathologic conditions using conven...
متن کاملTargeted Expression of Cre Recombinase Provokes Placental-Specific DNA Recombination in Transgenic Mice
BACKGROUND Inadequate placental development is associated with a high incidence of early embryonic lethality and serious pregnancy disorders in both humans and mice. However, the lack of well-defined trophoblast-specific gene regulatory elements has hampered investigations regarding the role of specific genes in placental development and fetal growth. PRINCIPAL FINDINGS By random assembly of ...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2004
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.10416